The Organelle does work with USB hubs. We have found that USB 2.0 hubs tend to work better than 3.0 ones (even if the 3.0 are supposed to be 2.0 compatible).
We haven’t looked into what the specific issue is with the Mac keyboards not working on the Organelle, but we did try an older (circa 2003 model) and it worked. Maybe the newer ones are sending non-standard information designed for the mac OS?