Yes it is possible.
I am sure I will forget something, because I did it two years ago and did not use it that much.
You have to install python-2.7.7
Then you have to install pygame on the python commandline (several dependencies will be asked for)
Then you have to get ETC_Mother and ETC_Sys from github:
Then you have create folders for the data on the USB drive and the you must enter the paths in the following files: (those path names are examples from my installation!):
etc_system.py: GRABS_PATH = "D:\\privat\\synths\\critter\\Grabs\\"
etc_system.py: MODES_PATH = "D:\\privat\\synths\\critter\\Modes\\"
etc_system.py: SCENES_PATH = "D:\\privat\\synths\\critter\\Scenes.csv"
main.py: file = open("D:\\privat\\synths\\critter\\MIDI-Channel.txt", "r")
main.py: if event.key == pygame.K_PERIOD: etc.update_trig_button(0)
osd.py: font = pygame.font.Font("D:\\privat\\synths\\critter\\root\\ETC_Mother\\font.ttf", 150)
osd.py: font = pygame.font.Font("D:\\privat\\synths\\critter\\root\\ETC_Mother\\font.ttf", 32)
osd.py: mode_str = " Memory Used: " + str(int(etc.memory_used) + 1) + "% "
osd.py: font = pygame.font.Font("D:\\privat\\synths\\critter\\root\\ETC_Mother\\font.ttf", 24)
finally you have to start the whole thing from the commandline like:
There will be a lot of errors on the first tries, because there are features which are not present, so you have to comment them out. For testing you may use this ETC_Mother directory:
But be aware the files contain also some other changes (especially for control via keyboard).
I hope this helps.