Yes, the original Organelle’s USB ports do class-compliant USB-MIDI, and can do serial communication. (Serial communication is great but I’m not aware of many people using this.)
USB-MIDI is covered in the original Organelle Manual: Critter & Guitari Manual
Here’s a video demonstrating different USB-MIDI setups with the original Organelle. These setups will all work with the Organelle M & S too.